Latest technologies from Aligo Innovation Inc.

Système de chauffage radiant ponctuel et localisé pour procédé de dépôt par filament fondu

innovation@axelys.ca — Fri, 03 Jul 2026 05:57:53 GMT

THERMALLY CONTROLLED ADDITIVE MANUFACTURING PRINTHEAD FOR HIGH-PERFORMANCE PARTS Unlocking the full potential of additive manufacturing without extra cost Coalia UNMET NEED Mechanical integrity is an ongoing challenge for 3D printed parts. Compared to injection molding, parts manufactured by material extrusion (FDM) suffer from a high degree of anisotropy, due to the lack of adhesion of the layers to each other, and therefore a general reduction in mechanical properties, which hinders the adoption of this type of manufacturing process at a reasonable cost. ...

NEW HIGH PRECISON 3D PRINTING HEAD FOR BIOPRINTERS

innovation@axelys.ca — Tue, 09 Jun 2026 13:45:00 GMT

NEW HIGH PRECISON 3D PRINTING HEAD FOR BIOPRINTERS Redefining bioprinting accuracy with vortex-driven mist polymerization UNMET NEED Alginate substrates commonly used in biomaterials and tissue engineering offer important characteristics such as biocompatibility, room-temperature polymerization, and relatively low cost. However, currently, the 3D systems lead to a substrate non defined, and more like a cluster than a grid, which limits tissue growth. TECHNOLOGY OVERVIEW The patented invention includes an innovative misting mechanism, added to a standard ...

A Physiologically Accurate Bladder Flow Simulator for Controlled Ureteral Jet Analysis

innovation@axelys.ca — Mon, 08 Jun 2026 20:52:00 GMT

A PHYSIOLOGICALLY ACCURATE BLADDER FLOW SIMULATOR FOR CONTROLLED URETERAL JET ANALYSIS New opportunities for diagnostic R&D and personal training UNMET NEED Ultrasound visualization of ureteral jets can be used to assess urinary tract function, yet its diagnostic value remains limited by high inter-patient variability and poor experimental controllability. This lack of reproducibility restricts the ability to correlate jet characteristics with specific pathological conditions such as kidney stone development and chronic kidney disease. Such conditions progressi...

The Rhythms & Background (RnB) algorithm for EEG signals

innovation@axelys.ca — Mon, 08 Jun 2026 20:42:09 GMT

THE RHYTHMS & BACKGROUND (RNB) ALGORITHM FOR EEG SIGNALS A better understanding of your EEG signals UNMET NEED Electrophysiological recordings consist of rhythmic and ubiquitous aperiodic activity. Growing evidence suggests that rhythmic and aperiodic components of EEG signals reflect distinct neurophysiological processes, motivating efforts to characterize their individual contributions. TECHNOLOGY OVERVIEW The Rhythms & Background (RnB) algorithm is a wavelet-based signal-processing method that filters out aperiodic activity from EEG recordings. This yields a s...

A Connected Garment for Real-Time 3D Monitoring of Spinal Deformities

innovation@axelys.ca — Mon, 08 Jun 2026 20:26:14 GMT

A CONNECTED GARMENT FOR REAL-TIME 3D MONITORING OF SPINAL DEFORMITIES Continuous monitoring for adaptive therapeutic management UNMET NEED Adolescent idiopathic scoliosis requires continuous monitoring to assess curve progression and brace efficiency, yet current clinical practice relies heavily on intermittent radiographic imaging, exposing young patients to repeated ionizing radiation and providing only limited insight into day‑to‑day posture. TECHNOLOGY OVERVIEW This technology introduces a wearable, radiation‑free solution for continuo...

Agrégation des globules rouges

innovation@axelys.ca — Thu, 21 May 2026 12:56:57 GMT

DEVICE FOR MONITORING OF INFECTION AND INFLAMMATION IN REAL-TIME Realtime and non-invasive detection and monitoring of infections and inflammatory response by measuring erythrocyte aggregation Credit: Cleveland Clinic UNMET NEED Despite the effectiveness of the current treatments and procedures, chronic hemodialysis patients live with debilitating life conditions, which are mainly due to their high vulnerability and propensity to develop severe and life-threatening infections that require frequent hospitalizations. This increased risk is explained by the frequent ...

Nouveaux inhibiteurs du VIH-1

innovation@axelys.ca — Wed, 06 May 2026 19:21:21 GMT

STRATEGY FOR HIV RESERVOIR DETECTION AND ELIMINATION Combination of a novel “HIV reservoir” detection methodology and effective elimination offers a unique opportunity for HIV Cure UNMET NEED Globally, about 40.8M people are living with HIV and it is estimated that over a million people are newly diagnosed every year (UNAIDS, 2025). While modern ART therapy is effective in controlling viral replication and extends life of patients, it does not offer a definitive cure, and patients eventually succumb to HIV-related comorbidities and diseases. Developing a curative approa...

3D MITHRIL – APPLICATEUR EN COTTE DE MAILLES POUR LA PLÉSIOTHÉRAPIE

innovation@axelys.ca — Fri, 01 May 2026 15:35:25 GMT

MESH APPLICATOR FOR SURFACE BRACHYTHERAPY Novel applicator designed to facilitate and accelerate the clinical workflow of surface brachytherapy UNMET NEED It is estimated that about 1.2M people are diagnosed with skin cancer every year. Despite the progress in therapy development, the death rate from skin cancer remains significant, especially at later stages. Surface brachytherapy (or plesiotherapy) is a widespread treatment option for non-melanoma type skin cancers and other benign lesions with high prevalence, such as Dupuytren’s disease and keloids. However, the commerci...

Smart-D

innovation@axelys.ca — Mon, 30 Mar 2026 06:46:56 GMT

Boreal Conductors SUPPORTED BY AXELYS At a glance Boreal Conductors is currently developing a superconducting power cable with integrated fault current limiting capabilities. Such technology will allow to make electrical networks more resilient and can be installed in locations where space is limited. Click here to visit their website: https://borealconductors.com/ Conducteurs Boréal ACCOMPAGNÉ PAR AXELYS En quelques mots Conducteurs Boréal développe un câb...

Rondelle intelligente de hockey sonore

innovation@axelys.ca — Tue, 17 Feb 2026 08:30:01 GMT

AUDIBLE HOCKEY PUCK A smart audible device for visually impaired and blind hockey players iStock - 183286613 UNMET NEED To improve their inclusion, multiple organisms have the mission to encourage visually impaired and blind people to participate in sport activities at all levels, from grassroots to the Paralympic Games. Some sports have been exclusively conceived for blind people (ex: goalball) been adapted via sound balls. Current blind hockey pucks consist of tomato cans and large hockey plastic pock with bearing. These devices are deformable, poorly identif...

Dreamient

innovation@axelys.ca — Tue, 10 Feb 2026 08:49:35 GMT

MOBILE APP FOR NIGHTMARE TREATMENT Mobile application used as therapy of nightmares and PTSD event by method of Neutralization of Anticipated Events (NAE) Credit : ©iStock/Koldunov; National Archives UNMET NEED Millions of people worldwide suffer from recurring nightmares and PTSD. Unfortunately, the effectiveness of current treatments is limited. For example, the standard treatment (IRT) has partial remission rates and lacks a clear theoretical basis. In addition, nearly 70% of people suffering from chronic nightmares do not seek treatment, either because t...

Prémac

innovation@axelys.ca — Thu, 22 Jan 2026 07:55:49 GMT

HAMMOCK FOR NICU INCUBATORS Hammock optimized for use in NICU incubators to improve newborn physiological conditions and safety Source: NeoWell UNMET NEED Each year in the world, about 900,000 premature babies die because of prematurity complications, which may be due to the stressful environments and interventions that newborns are exposed to in the first weeks of life. The positioning of newborns in neonatal intensive care units (NICU) incubators can contribute to their physiological stability and sleep quality. A few studies have demonstrated that the use of hammocks ...

MicroARN miR-423-5p

innovation@axelys.ca — Sat, 10 Jan 2026 10:01:34 GMT

NOVEL TREATMENT FOR MICROVESSEL RAREFACTION Innovative treatment for microvessel rarefaction that contributes to the dysfunction of several organs Credit Shutterstock : 2447014671 UNMET NEED During major surgery, sepsis, trauma, or kidney transplantation, interruption of renal blood flow followed by kidney reperfusion (ischemia-reperfusion) causes tubular injury and endothelial cell damage that leads to renal dysfunction, acute kidney injury and to chronic or progressive renal failure. An estimated 35.5 million Americans have kidney disease and about 815 000 American...

Échafaudage super déformable inspiré de l'origami pour l'ostéogenèse par distraction

innovation@axelys.ca — Sat, 10 Jan 2026 07:18:29 GMT

ORIGAMI INSPIRED FLAT-FOLDABLE SCAFFOLD (OIFFS) FOR DISTRACTION OSTEOGENESIS Innovative solution to accelerate bone healing after the distraction surgical process UNMET NEED Congenital limb asymmetry, complex long-bone fractures caused by accidents, and segmental bone loss following tumor resection are common clinical conditions that affect more than one-third of the population. If not properly treated, these cases can lead to serious long-term musculoskeletal and joint complications, including hip dysplasia, and scoliosis. The gold-standard regenerative technique ...

MicroARN miR-423-5p

innovation@axelys.ca — Wed, 03 Dec 2025 09:00:33 GMT

NOVEL BIOMARKERS FOR MICROVESSEL RAREFACTION Prevention/monitoring of the microvessel rarefaction that contributes to several organ dysfunctions Credit Shutterstock : 2447014671 UNMET NEED During major surgery, sepsis, trauma, or kidney transplantation, interruption of renal blood flow followed by kidney reperfusion (ischemia-reperfusion) causes tubular injury and endothelial cell damage that leads to renal dysfunction, acute kidney injury and to chronic or progressive renal failure. An estimated 35.5 million Americans have kidney disease and about 815 000 Americans ...

Crossed-linked biochar-sulfur materials and methods of preparation of the same

innovation@axelys.ca — Fri, 28 Nov 2025 09:10:08 GMT

SCALABLE BIOCHAR-SULFUR MATERIAL FOR SUSTAINABLE APPLICATIONS A new vulcanized biochar combines high strength with ultralight weight, demonstrating how biomass residues can be transformed at scale into an engineered carbon material – opening opportunities in construction, composites, and energy applications. Credit Université de Montréal UNMET NEED Biochar is emerging as a useful product to capture carbon from biomass residues and waste management streams. Produced by the oxygen-free pyrolysis of biomass, it transforms organic waste in a lightw...

Sonde ultrasonores multi-élément en transmission axiale pour la caractérisation in-vivo des propriétés osseuses du radius

innovation@axelys.ca — Mon, 17 Nov 2025 07:21:12 GMT

PORTABLE ULTRASOUND DEVICE FOR OSTEOPOROSIS DIAGNOSIS A novel ultrasound probe that allows for low-cost and rapid evaluation of bone characteristics and diagnosis and follow-up of osteoporosis Source: Cleveland Clinic UNMET NEED Osteoporosis is an age-related disease characterized by loss of bone density in individuals. Today, osteoporosis affects more than 250 million people worldwide and becomes an increasingly prevalent disease due to ageing population. Osteoporosis is a significant threat to affected population since it is a root cause of higher susceptibility t...

Faraday shielding of beam current transformer for ultra-high dose rate electron beam monitoring

innovation@axelys.ca — Thu, 13 Nov 2025 10:17:36 GMT

MAKING FLASH RADIOTHERAPY SAFER Electrostatic shielding for accurate dose monitoring Credit Shutterstock : 2146616441 UNMET NEED The development of ultra-high dose rate (UHDR) or FLASH radiotherapy offers a promising cancer treatment by delivering intense radiation bursts that spare healthy tissue while effectively targeting tumors. However, a significant barrier to broader clinical adoption is an inaccurate dosimetry, real-time monitoring of beam current and energy in compliance with IEC 60601-2-1:2020 standards, in absence of which the safet...

Use of Schistosoma mansoni Cathepsin B (antigen) and Addavax (adjuvant) as vaccine to protect from Schistosomiasis

innovation@axelys.ca — Tue, 23 Sep 2025 11:41:42 GMT

NOVEL VACCINE AGAINST SCHISTOSOMIASIS A powerful combination of vaccine targeting Schistosoma mansoni cathepsin B with Addavax adjuvant results in highly efficient immunization against the parasite Source: CDC UNMET NEED Schistosomiasis affects over 200 million people worldwide and has a significant economic burden (~$50 billion US), especially in developing countries. The female population is especially vulnerable, since the disease leads to complications and increases risks of comorbidities. Current treatment lacks efficacy as it does not prevent reinfection and...

Calogy Solutions

innovation@axelys.ca — Thu, 11 Sep 2025 08:10:42 GMT

Calogy Solutions SUPPORTED BY AXELYS At a glance Calogy Solutions is focused on solving complex thermal management problems and providing innovative solutions in diverse industries, including microelectronics, medical devices, and electrical transportation. Click here to visit their website: https://www.calogysolutions.com/ Calogy Solutions ACCOMPAGNÉ PAR AXELYS En quelques mots Calogy Solutions se dédie à la résolution de problèmes complexes de gestion thermique et fournit des solutions...

Bliq Photonique

innovation@axelys.ca — Thu, 11 Sep 2025 08:10:40 GMT

Bliq Photonique SUPPORTED BY AXELYS At a glance Bliq Photonique specializes in the manufacturing of complete multiphoton imaging systems. The company integrates imaging innovation into the device systems and develops its own operating software to provide high-performance, reliable, and easy-to-use microscopy products. Click here to visit their website: https://bliqphotonics.com Bliq Photonique ACCOMPAGNÉ PAR AXELYS En quelques mots Bliq Photonique se spécialise dans la fabrication de système d’im...

Baton Simulations

innovation@axelys.ca — Thu, 11 Sep 2025 08:10:38 GMT

Baton Simulations

Castor Optics

innovation@axelys.ca — Thu, 11 Sep 2025 08:10:34 GMT

Castor Optics SUPPORTED BY AXELYS At a glance Castor Optics is a Montreal-based leading manufacturer of specialized fiber components and engines. Castor uses its expertise to develop and manufacture customized couplers and/or assemblies to suit the customer's application. Source : https://www.castoroptics.com/ Click here to visit their website: https://www.castoroptics.com/en/ Castor Optics ACCOMPAGNÉ PAR AXELYS . En quelques mots Castor Optique est un chef de file montréa...

Mirror Effect Plus Protocol (MEPP) 2.0: plate-forme de rééducation faciale

innovation@axelys.ca — Thu, 12 Jun 2025 12:05:05 GMT

MEPP: A REVOLUTIONARY WEB PLATFORM FOR FACIAL REHABILITATION An innovation combining mirror therapy and augmented reality UNMET NEED Each year, approximately 2.4 million people suffer from Bell’s palsy, and another 2 million develop facial paralysis following a stroke. Between 20% and 30% of this affected population would require facial rehabilitation. However, access to effective and early rehabilitation remains limited, leading many patients to turn to scientifically unvalidated approaches. The resulting facial aftereffects (muscle weakness, asymmetry, chro...

Detection of HIV-1 soluble gp120 in biological fluids

innovation@axelys.ca — Thu, 12 Jun 2025 09:10:49 GMT

HIV GP120 MONITORING IN BODY FLUIDS Personalized medicine tool for patient stratification and follow-up of fostemsavir (Rukobia) treatment based on the detection of HIV soluble gp120 in biological fluids HIV-CD4 binding mechanism Reference : Zuru DU, Sci African 6: e00177, 2019. UNMET NEED A significant number of people living with HIV (PLWH) and undergoing antiretroviral therapy are presented with chronic inflammation due to gp120 viral protein release in blood. Indeed, the gp120 subunit of HIV-1 envelope, involved in interactions with CD4+ T cells, can be ...

CBLs as a biomarker of and target to treat systemic lupus erythematosus (SLE)

innovation@axelys.ca — Thu, 12 Jun 2025 07:40:57 GMT

SLE DIAGNOSTIC TOOL CBL protein levels used as a molecular diagnostic marker to diagnose and assess severity of Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus patient (photo: NCRD) UNMET NEED Systemic Lupus Erythematosus (SLE) is an autoimmune disease, especially prevalent in women, and without curative treatment. In addition, the diagnosis of the disease is complicated due to heterogeneity of manifestations and symptoms. The severity of SLE also varies significantly, thus affecting choices of symptom treatment. With existing diagnostic tools, it takes ...

Novel Ti02

innovation@axelys.ca — Wed, 11 Jun 2025 08:51:16 GMT

OXYGEN SCAVENGER COMPOSITION FOR SENSITIVE PHARMACEUTICAL PACKAGING Enhanced oxygen absorption films for preserving sensitive pharmaceutical and biopharmaceutical products in low humidity and dry conditions Source : Glassonline.com UNMET NEED Oxygen poses significant challenges to the stability and longevity of sensitive products like biologics, DEA schedule II and IV drugs, parenterals, and others requiring extended shelf life. The presence of oxygen can lead to various forms of degradation and failure modes in these products. To address this issue, modern...

Novel Antisense Oligonucleotides Targeting RAPTOR Expression to Improve the Pathological Consequences of Genetic Mutations Causing mTORC1 Hyperactivity, including GATOR1 and TSC mutations.

innovation@axelys.ca — Wed, 21 May 2025 12:10:57 GMT

NOVEL RNA INTERFERENCE AGENTS TARGETING mTORC1 ACTIVITY New hope for epilepsy and autism spectrum disorders (ASD) Shutterstock : 2203572829 UNMET NEED Epilepsy and Autism Spectrum Disosrder (ASD) are significant public health concerns, affecting over 65 million people worldwide for epilepsy and 1 in 100 children worldwide (1 in 36 children in US) for ASD. Despite being traditionally viewed as independent neurological diseases, recent genomic sequencing studies have uncovered multiple genes linked to both conditions. Notably, mutations in the NPRL2, NP...

NEW METHODS FOR INCREASING POLYMORPHIC DIVERSITY

innovation@axelys.ca — Wed, 21 May 2025 10:32:14 GMT

NEW METHODS FOR INCREASING POLYMORPHIC DIVERSITY Increasing the value of your portfolio of compounds by finding new solid forms with better properties Shutterstock : 2448730807 UNMET NEED Most compounds can exist in multiple crystalline forms, called polymorphs. The phenomenon of polymorphism has been known for centuries but remains poorly understood, despite intensive study. Computational methods for predicting how molecules will crystallize are becoming increasingly powerful; however, they remain unreliable for analyzing molecules of even modest complexity...

Methods and composition for gene editing at the transferrin locus

innovation@axelys.ca — Wed, 21 May 2025 08:53:24 GMT

GENE EDITING TOOLBOX Cas-9-based proprietary tools for gene editing, better production and efficient CAR-T cells, and/or transfer of therapeutic proteins across the blood-brain barrier Shutterstock : 2166283693 UNMET NEED Pediatric metabolic diseases. There is currently no approved long-term therapy or cure for several diseases such as type tyrosinemia or neurological lysosomal mucopolysaccharidosis (Hurler, Hurler-Scheie, Hunter, Sly and Sanfilippo syndromes). Lysosomal diseases generally appear in the fetus during pregnancy or in newborns an...

Layer-by-layer modified lipid nanoparticles for enhanced gene and drug delivery and applications thereof

innovation@axelys.ca — Tue, 20 May 2025 08:42:49 GMT

LAYER-BY-LAYER MODIFIED LNPs : GENE & DRUG DELIVERY New layer-by-layer (LbL) assembled Lipid nanoparticles (LNPs) platform for high biomolecule loading, staged release, adequate protection of cargo and modulated targeting property. Shutterstock : 2166283693 UNMET NEED The development of nanocarriers capable of encapsulating, targeting, and delivering Drug Substances (DS) has become the main challenging issue during the last three decades for biotechnology and pharmaceutical industries. Ideally, an optimal drug delivery system would be able to promote high encaps...

Poly (monoglycerol acrylate) - PMGA

innovation@axelys.ca — Tue, 20 May 2025 05:44:46 GMT

POLY (MONOGLYCEROL ACRYLATE) New alternative to PEG in lipid nanoparticles (LNP) Shutterstock : 2203572829 UNMET NEED Poly (ethylene glycol) (PEG) is widely used in pharma to 1) prepare bioconjugates and 2) generate lipid nanoparticles (LNPs). In LNPs that contain nucleic acids, PEG-lipids facilitate the preparation of stable colloids, but serve little biological function. In fact, to allow nanoparticles to interact with their target cells, PEG-lipids must desorb from the surface of the LNPs in vivo. In parallel, treating patients with PEGylated drugs/nanoparticles...

Agonistic antibodies against SLAMF7 for improved immunotherapy against human cancer

innovation@axelys.ca — Thu, 15 May 2025 12:47:39 GMT

NOVEL MULTIPLE MYELOMA THERAPY THROUGH SIRP-ALPHA AND SLAM7 BLOCKADE New and first-in-class anti-SLAMF7 monoclonal antibody (Z10) Credit Shutterstock : 1878567847 UNMET NEED Multiple myeloma is a hematological cancer characterized by a clonal expansion of plasma cells. There are approximatively 2500 new cases per year in Canada and 35000 in the United States. Current treatments for multiple myeloma include small molecules, monoclonal antibodies (mAbs) and cell therapies. Despite important therapeutic advances, the current net myeloma s...

Angiographie Myocardique Ultrasonore Super Résolue (MULA)

innovation@axelys.ca — Thu, 15 May 2025 08:21:40 GMT

HIGH RESOLUTION ANGIOGRAPHY IN MOVING ORGANS Dynamic Myocardial Ultrasound Localization Angiography (MULA) Credit Shutterstock : 649269142 UNMET NEED In patients with known or suspected coronary heart disease, cardiac imaging tests are often the first step in diagnosis and treatment planning. However, they remain for the most part limited to the coronary vasculature located on the surface of the heart, not to the intramyocardial vasculature located inside the myocardial muscle. Intra myocardial vasculature can be mapped non-invasively in the beating ...